Everything about ceesdekker

Everything about ceesdekker

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Utilizing single-molecule optical and AFM imaging and force-spectroscopy approaches, we find to unravel the mechanistic elements of the composition and dynamics of chromosomes. Our investigation passions consist of:

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Sculpting nano-electrodes using a transmission electron beam for electrical and geometrical characterization of nanoparticles.

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and to start with ever study from the dynamics DNA supercoils and the invention of supercoil hopping

Example (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is shown in grey, the rim with the pore is highlighted in red, as well as a 3D rendering of your motion in the DNA rod is exhibited.

Size Charge of specific carbon nanotubes by nanostructuring Using the scanning tunneling microscope

Finding out DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.

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Dekker begun his exploration on single carbon nanotubes in 1993 when he set up a different line of analysis to check electrical transport through solitary organic molecules concerning nanoelectrodes. In 1996 a breakthrough was recognized with carbon nanotubes. This was achieved in a very collaboration With all the team of Nobel laureate Richard Smalley. STM and nanolithography strategies were being accustomed to demonstrate that these nanotubes are quantum wires at The only-molecule amount, with fantastic physical Attributes.

Instance (4) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in grey, the rim of the pore is highlighted in pink, and also a 3D rendering in the motion of your DNA rod is shown.

2006, to start with demonstration of molecular sorting inside of a lab on a chip using biomotors; discovery of nanobubbles in sound-condition nanopores; and to start with estimate of electrokinetic Power conversion in the nanofluidic channel

2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; discovery of extensive-variety conformational alterations in Mre11/DNA maintenance complexes; and initial power measurements over a DNA molecule in a very nanopore

 Lastly, I will briefly sketch some of our ideas to explore the building of artificial cells, specially our initially methods to https://www.ceesdekker.net ascertain synthetic mobile division.